HB-0025 is under clinical development by Huabo Biopharm (Shanghai) and currently in Phase I for Solid Tumor. According to GlobalData, Phase I drugs for Solid Tumor have a 70% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how HB-0025’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

HB-0025 overview

HB-0025 is under development as a second line of therapy for the treatment of advanced solid tumors, squamous non-small cell lung cancer, non-squamous non-small cell lung cancer, endometrial cancer, hepatocellular carcinoma, colorectal cancer and metastatic renal cell carcinoma. It is administered through intravenous and intravenous drip route. It is a bi-specific fusion protein. The drug candidate is a recombinant humanized anti-PD-L1 monoclonal antibody-VEGFR1 fusion protein. 

Huabo Biopharm (Shanghai) overview

Huabo Biopharm Co Ltd (Huabobio), a subsidiary of Shanghai Huaota Biopharmaceutical Co Ltd, is a developer and marketer of therapies for the treatment of patients with tumors. The company develops drugs by using a bi-functional protein technology platform, domain protein technology and antibody engineering technology. Its pipeline products include HOT-101, HB0030, HB0025, HB002.1T, HOT-1030, HB0028, HB0036 and HB0039, among others. Huabobio’s antibody engineering technology and bi-functional protein technology platform support in development of protein and antibody drugs with improved therapeutic efficacy. The company promotes tumor metastasis at the late stage of tumor progression through inducing epithelial-mesenchymal transition, inhibiting tumor immunity; and tumor angiogenesis through induction of angiogenic mediators such as vascular endothelial growth factor. Huabobio is headquartered in Shanghai, China.

For a complete picture of HB-0025’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.