Iptacopan hydrochloride is under clinical development by Novartis and currently in Phase III for Atypical Hemolytic Uremic Syndrome (Nondiarrhea – Associated Hemolytic Uremic Syndrome). According to GlobalData, Phase III drugs for Atypical Hemolytic Uremic Syndrome (Nondiarrhea – Associated Hemolytic Uremic Syndrome) have a 67% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Iptacopan hydrochloride’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Iptacopan hydrochloride overview
Iptacopan (LNP-023) is under development for the treatment of glomerulonephritis- IgA nephropathy (Berger's disease), early to middle age-related macular degeneration, C3 glomerulopathy, proteinuria, atypical hemolytic uraemic syndrome, lupus nephritis, immune complex membranoproliferative glomerulonephritis and paroxysmal nocturnal hemoglobinuria. It is administered through oral route as a hard gelatin capsule. It acts by targeting complement factor B (FB). The therapeutic candidate is a new molecular entity (NME).
It was also under development for the treatment of idiopathic/primary membranous nephropathy.
Novartis is a healthcare company that focuses on the discovery, development, manufacture and marketing of prescription and generic pharmaceutical products and eye care products. It provides drugs for the treatment of cancer, cardiovascular diseases, dermatological conditions, neurological disorders, ophthalmic and respiratory diseases, hematologic diseases, solid tumors, immune disorders, and infections, among others. The company offers generic medicines and biosimilars through Sandoz. Novartis conducts research in various disease areas through The Novartis Institutes for BioMedical Research (NIBR). The company operates through a network of subsidiaries and offices across the Americas, Europe, the Middle East, Africa, and Asia-Pacific. Novartis is headquartered in Basel, Switzerland.
For a complete picture of Iptacopan hydrochloride’s drug-specific PTSR and LoA scores, buy the report here.