Linavonkibart is under clinical development by Scholar Rock and currently in Phase I for Head And Neck Squamous Cell Carcinoma (HNSC). According to GlobalData, Phase I drugs for Head And Neck Squamous Cell Carcinoma (HNSC) have a 79% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Linavonkibart’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Linavonkibart overview

Linavonkibart (SRK-181) is under development for the treatment of solid tumors including but not limited to bladder cancer, myelofibrosis, head and neck squamous cell carcinoma (HNSCC), urothelial cancer, non-small cell lung cancer, melanoma, clear cell renal cell carcinoma (ccRCC), myelofibrosis , breast cancer and ovarian cancer and oropharyngeal cancer. It acts by targeting transforming growth factor beta 1 (TGFB1). The drug candidate is developed using the supracellular activation technology platform.

Scholar Rock overview

Scholar Rock, a subsidiary of Scholar Rock Holding Corp, is a biopharmaceutical company that focuses on the discovery, development and delivery of life-changing therapies for serious diseases with high unmet needs. The company’s main activities involve harnessing cutting-edge science to create new possibilities for patients, with a particular emphasis on targeting growth factors in their inactive precursor forms to selectively regulate their activity. The company’s products include Apitegromab for Spinal Muscular Atrophy and Cardiometabolic Disorders, SRK-439 for novel antimyostatin antibody, SRK-181 for Immuno-Oncology and selective context-dependent treatments for Fibrosis and Anemia. Scholar Rock is headquartered in Cambridge, Massachusetts, the US.

For a complete picture of Linavonkibart’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.