Lonafarnib is under clinical development by Merck & Co and currently in the Phase I and Phase III in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Lonafarnib’s likelihood of approval (LoA) and phase transition for Hepatitis D took place on 12 Dec 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Lonafarnib Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Lonafarnib overview

Lonafarnib (Zokinvy) is a synthetic tricyclic derivative of carboxamide with antineoplastic properties. It is formulated as hard gelatin capsules for oral route of administration. Zokinvy is indicated in patients 12 months of age and older with a body surface area of 0.39 m2 and above to reduce risk of mortality in Hutchinson-Gilford Progeria Syndrome and for treatment of processing-deficient Progeroid Laminopathies with either Heterozygous LMNA mutation with progerin-like protein accumulation or Homozygous or compound heterozygous ZMPSTE24 mutations. Lonafarnib (Sarasar, SCH 66336) is under development for the treatment of Hepatitis D, brain tumors such as glioblastoma multiforme and gliosarcoma. It is a synthetic tricyclic derivative of carboxamide. Lonarfanib binds to and inhibits farnesyl transferase. It was also under development for the treatment of acute myelogenous leukemia, chronic myelogenous leukemia, acute lymphoblastic leukemia, non-small cell lung cancer, squamous cell carcinoma of the head and neck, myelodysplastic syndrome and chronic myelomonocytic leukemia (CMML), adenocarcinoma of prostate cancer and metastatic breast cancer.

Merck & Co overview

Merck & Co (Merck) is a biopharmaceutical company focused on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines and animal health products. It offers prescription products for therapy areas related to cardiovascular, cancer, immune disorders, infectious, respiratory and women’s diseases, and diabetes. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is known as MSD outside the US and Canada and is headquartered in Kenilworth, New Jersey, the US.

Quick View Lonafarnib LOA Data

Report Segments
  • Innovator (NME)
Drug Name
  • Lonafarnib
Administration Pathway
  • Oral
Therapeutic Areas
  • Genetic Disorders
  • Infectious Disease
  • Oncology
Key Developers
  • Sponsor Company: Merck & Co
  • Originator: Schering-Plough
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.