LP-352 is a small molecule commercialized by Longboard Pharmaceuticals, with a leading Phase II program in Lennox-Gastaut Syndrome. According to Globaldata, it is involved in 6 clinical trials, of which 3 were completed, and 3 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of LP-352’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

The revenue for LP-352 is expected to reach an annual total of $204 mn by 2036 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

LP-352 Overview

LP-352 (AN-352) is under development for the treatment of developmental and epileptic encephalopathies (DEEs) refractory focal epilepsies, Lennox-Gastaut Syndrome, dravet syndrome, tuberous sclerosis complex and CDKL5 deficiency disorder. It is administered by oral route. The drug candidate is developed based on Arena Neuroscience platform. It acts by targeting 5-Hydroxytryptamine Receptor 2C.

Longboard Pharmaceuticals Overview

Longboard Pharmaceuticals (Longboard) is a clinical-stage biopharmaceutical company that discover and develops novel, transformative medicines for neurological diseases. The company’s pipeline program includes LP352, an oral 5-HT2c super agonist targeting dravet syndrome, lennox-gastaut syndrome (LGS), tuberous sclerosis complex (TSC), CDKL5 deficiency disorder, and other epileptic disorders; LP143, a CB2 agonist against amyotrophic lateral sclerosis (ALS) and neuroinflammatory disorders; and LP659, S1P receptor modulator targeting multiple neuroinflammatory disorders. It is also developing medicines for the treatment of central nervous system neuroinflammatory diseases and epileptic encephalopathies. Longboard is headquartered in La Jolla, California, the US

The operating loss of the company was US$44.8 million in FY2022, compared to an operating loss of US$27.8 million in FY2021. The net loss of the company was US$44 million in FY2022, compared to a net loss of US$27.8 million in FY2021.

For a complete picture of LP-352’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 2 September 2023

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.