MB-107 is a gene-modified cell therapy commercialized by Mustang Bio, with a leading Phase II program in X-Linked SCID. According to Globaldata, it is involved in 1 clinical trial, which is ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of MB-107’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

The revenue for MB-107 is expected to reach an annual total of $5 mn by 2038 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

MB-107 Overview

MB-107 is under development for the treatment of X-linked severe combined immunodeficiency. The therapy comprises autologous CD34+ bone marrow cells transduced with a lentiviral vector that contains a normal copy of the human gamma c gene. The therapeutic candidate is administered through intravenous route.

Mustang Bio Overview

Mustang Bio is an US based developer of cell and gene therapies for the treatment of AML and brain cancer.

The operating loss of the company was US$66.7 million in FY2021, compared to an operating loss of US$56.8 million in FY2020. The net loss of the company was US$66.4 million in FY2021, compared to a net loss of US$60 million in FY2020.

For a complete picture of MB-107’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.