MK-4830 is under clinical development by Merck and currently in Phase II for Peritoneal Cancer. According to GlobalData, Phase II drugs for Peritoneal Cancer have a 37% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how MK-4830’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

MK-4830 overview

MK-4830 is under development for the treatment of solid tumors such as metastatic pancreatic adenocarcinoma, colorectal cancer, glioblastoma multiforme, metastatic renal cell carcinoma (RCC), esophageal squamous cell carcinoma (ESCC), recurrent or metastatic head and neck squamous cell cancer (HNSCC) of the oral cavity, oropharynx, hypopharynx, and/or larynx, mesothelioma, metastatic breast cancer, triple-negative breast cancer, high-grade epithelial ovarian, fallopian tube or primary peritoneal carcinoma, metastatic pancreatic adenocarcinoma, metastatic non-small-cell lung cancer, metastatic non-squamous non-small-cell lung cancer, small cell lung cancer, renal cell cancer and recurrent and/or metastatic gastric or gastroesophageal junction adenocarcinoma. The drug candidate comprises of human IgG4 monoclonal antibody and is developed based on retrocyte display technology and secant yeast display technology. It is administered through intravenous route. The drug candidate acts by targeting immunoglobulin like transcript 4. 

Merck overview

Merck is a biopharmaceutical company focused on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines, and animal health products. It offers prescription products for therapy areas related to cardiovascular, cancer, immune disorders, infectious, respiratory, and diabetes. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is known as MSD outside the US and Canada and is headquartered in Kenilworth, New Jersey, the US.

For a complete picture of MK-4830’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.