MK-5475 is under clinical development by Merck and currently in Phase III for Idiopathic Pulmonary Hypertension. According to GlobalData, Phase III drugs for Idiopathic Pulmonary Hypertension does not have sufficient historical data to build an indication benchmark PTSR for Phase III. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the MK-5475 LoA Report. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
MK-5475 overview
MK-5475 is under development for the treatment of pulmonary hypertension, pulmonary vascular resistance in patients with pulmonary arterial hypertension including idiopathic, heritable, drug- or toxin-induced pulmonary hypertension and pulmonary hypertension associated with connective tissue disease or congenital heart disease and pulmonary hypertension associated with chronic obstructive pulmonary disease. The drug candidate is administered through inhalation route. It was also under development for hypoxemia due to Coronavirus disease 2019 (COVID-19) pneumonia. The drug candidate acts by targeting soluble guanylate cyclase (SGC).
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Merck overview
Merck is a biopharmaceutical company focused on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines, and animal health products. It offers prescription products for therapy areas related to cardiovascular, cancer, immune disorders, infectious, respiratory, and diabetes. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is known as MSD outside the US and Canada and is headquartered in Kenilworth, New Jersey, the US.
For a complete picture of MK-5475’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
