Mosunetuzumab is under clinical development by Genentech USA and currently in Phase II for Refractory Chronic Lymphocytic Leukemia (CLL). According to GlobalData, Phase II drugs for Refractory Chronic Lymphocytic Leukemia (CLL) have a 27% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Mosunetuzumab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Mosunetuzumab (Lunsumio) is a bi-specific monoclonal antibody works by allowing one arm to target B cell antigen CD20 and the other arm to recruit T cells by binding to CD3 of the T-cell receptor. It is formulated as concentrated solution and solution for intravenous and subcutaneous route of administration. Lunsumio is indicated for the treatment of adult patients with relapsed or refractory follicular lymphoma (FL) who have received at least two prior systemic therapies.
Mosunetuzumab is under development for the treatment of diffuse large b-cell lymphoma, follicular lymphoma, vesicular lymphoma, primary mediastinal b-cell lymphoma and high grade b-cell lymphoma (HGBCL), relapsed or refractory b-cell acute lymphoblastic leukemia, relapsed and refractory hematological tumors like high-grade B-cell lymphoma (HGBCL), chronic lymphocytic leukemia, non-Hodgkin lymphomas including follicular lymphoma, mantle cell lymphoma, diffuse large B-cell lymphoma. It is administered intravenously and subcutaneously. The drug candidate is a bi-specific antibody targeting CD20 expressing cells by recruiting CD3 T-cells. The drug candidate is developed based on knobs-into-hole technology. It was also under development for marginal zone lymphoma, primary mediastinal B-cell lymphoma and small lymphocytic lymphoma.
For a complete picture of Mosunetuzumab’s drug-specific PTSR and LoA scores, buy the report here.