MTL-CEBPA is under clinical development by Mina Therapeutics and currently in the Phase I and Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect MTL-CEBPA’s likelihood of approval (LoA) and phase transition for Solid Tumor took place on 27 Jun 2022, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their MTL-CEBPA Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

MTL-CEBPA overview

MTL-CEBPA is under development for the treatment of non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), liver failure and  solid tumors including hepatocellular carcinoma, breast cancer, lung cancer, ovarian cancer, pancreatic cancer, gall bladder cancer, neuroendocrine tumor, fallopian tube cancer, renal cancer, malignant mesothelioma, melanoma, glioblastoma multiforme, cholangiocarcinoma and mucopolysaccharidosis I (MPS I) hurler syndrome. The therapeutic candidate is administered through intravenous route. It is a SMARTICLES liposomal formulation of MTL-501. MTL-501 is a short activating RNA targeting the CEBPA gene. It is developed based on SMARTICLES delivery technology. SMARTICLES are amphoteric liposomes composed of combinations of lipids having anionic and cationic groups that work together to enable cell uptake. It was under development for the treatment of liver cirrhosis.

Mina Therapeutics overview

Mina Therapeutics, a subsidiary of MiNA (Holdings) Ltd, is a developer of small activating ribonucleic acid therapeutics that selectively upregulate therapeutic proteins. The company’s lead therapeutic, MTL-CEBPA, is developed for the treatment of liver cancer. It also offers evaluation programs for the treatment of liver cirrhosis, non-alcoholic steatohepatitis, non-alcoholic fatty liver disease, and other medical conditions. Mina Therapeutics develops therapeutics using its proprietary RNA activation technology platform. The company collaborates with drug delivery companies for the development of saRNA. It operates through its offices and laboratories in the UK. Mina Therapeutics is headquartered in London, Greater London, the UK.

Quick View MTL-CEBPA LOA Data

Report Segments
  • Innovator
Drug Name
Administration Pathway
  • Intravenous
Therapeutic Areas
  • Gastrointestinal
  • Genetic Disorders
  • Oncology
Key Developers
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.