Nabiximols is a Small Molecule owned by Jazz Pharmaceuticals, and is involved in 61 clinical trials, of which 54 were completed, 2 are ongoing, and 5 are planned.
Sativex (nabiximols) contains a standardized extract of tetrahydrocannabinol (THC), the non-psychoactive cannabinoid cannabidiol (CBD), other minor cannabinoids, flavonoids, and terpenes from two cannabis plant varieties. Cannabinoids interact with G protein-coupled cannabinoid 1 (CB1) receptors in the central nervous system, resulting in analgesic, euphoric, and anti-convulsive effects. the active ingredients of Sativex exert their effects upon CB1 receptor and the CB2 receptor. CB1 receptors are thought to exert their effects in the brain while CB2 receptors are thought to exert their effects on immune cells. THC has its effect by inhibiting cyclic AMP (part of the cellular energy generation process), through G-protein coupling in target cells, which cluster in areas of the central nervous system that mediate pain, memory, and other key functions. THC bind weakly to the cannabinoid type one (CB1) receptors, which are found in the brain and are called partial agonists.
The revenue for Nabiximols is expected to reach a total of $894m through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Nabiximols NPV Report.
Nabiximols (Sativex, OPC-33300) was composed of two principal cannabinoid components, cannabidiol (CBD) and delta-9 tetrahydrocannabinol, also called as tetrahydrocannabinol (THC). Cannabidiol (CBD) is a cannabinoid found in Cannabis. THC or dronabinol is the main psychoactive substance found in the cannabis plant. It is formulated as mucosal spray for oral route of administration. Sativex is indicated as treatment or for symptom improvement in patients with moderate to severe spasticity due to multiple sclerosis (MS) and as adjunctive analgesic treatment in adult patients with advanced cancer who experience moderate to severe pain during the highest tolerated dose of strong opioid therapy for persistent background pain and as adjunctive treatment for the symptomatic relief of neuropathic pain in multiple sclerosis in adults.
Nabiximols (Sativex) was under development for the treatment of agitation in dementia, muscle spasticity due to multiple sclerosis, spinal cord spasticity, peripheral neuropathic pain. Nabiximols was under development for the treatment of cancer pain in the U.S. It was also under development for the treatment of cancer pain, postherpetic neuralgia, postoperative pain, post-operative nausea, recurrent glioblastoma multiforme and vomiting, anxiety disorders.
It was also under development for the treatment of post traumatic stress disorder.
Almirall is a specialty pharmaceutical company that researches, develops, manufactures, and commercializes proprietary medicines and licensed products. The company’s major area of focus is dermatology covering psoriasis, eczema, acne, and other skin infections. It also develops products for autoimmune diseases including rheumatoid arthritis and multiple sclerosis; and gastrointestinal diseases including irritable bowel syndrome with constipation. The company also works together with small and medium-sized companies and healthcare professionals to develop medical solutions and provide them to patients. It operates through affiliates in Europe and Central America and has R&D centers in Spain and Germany. Almirall is headquartered in Barcelona, Spain.
The company reported revenues of (Euro) EUR827.2 million for the fiscal year ended December 2021 (FY2021), an increase of 2.4% over FY2020. In FY2021, the company’s operating margin was 0.7%, compared to an operating margin of 11.4% in FY2020. The net loss of the company was EUR40.9 million in FY2021, compared to a net profit of EUR74.3 million in FY2020. The company reported revenues of EUR197.2 million for the third quarter ended September 2022, a decrease of 54.8% over the previous quarter.
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