Odronextamab is a monoclonal antibody commercialized by Zai Lab, with a leading Phase III program in Primary Mediastinal B-Cell Lymphoma. According to Globaldata, it is involved in 13 clinical trials, of which 10 are ongoing, and 3 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of Odronextamab’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Odronextamab is expected to reach an annual total of $80 mn by 2036 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Odronextamab Overview

Odronextamab is under development for the treatment of relapsed/refractory B- cell non-Hodgkin's lymphomas including relapsed/refractory diffuse large B-cell lymphoma, relapsed/refractory follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, Burkitt Lymphoma, primary mediastinal large B-cell lymphoma and acute lymphoblastic leukemia. The therapeutic candidate is administered intravenously. It is an anti-CD20 and anti-CD3 bi-specific monoclonal antibody. It is developed based on VelociSuite technology. It was under development for B-cell Hodgkin's lymphoma.

Zai Lab Overview

Zai Lab biopharmaceutical company that carries out drug development, discovery and commercializing therapies. The company product pipeline includes ZEJULA (niraparib), qinlock (ripretinib) NUZYRA (omadacycline) and optune (tumor treating fields). It includes discovering, developing and commercializing products that address medical conditions. Zai Lab therapeutic areas includes oncology, autoimmune disorders, infectious diseases and neuroscience. The company market its products to the United States, Europe, Canada, Australia, Greater China and certain other countries and regions. Zai Lab is headquartered in Shanghai, China.
The company reported revenues of (US Dollars) US$266.7 million for the fiscal year ended December 2023 (FY2023), an increase of 24% over FY2022. The operating loss of the company was US$366.6 million in FY2023, compared to an operating loss of US$404.4 million in FY2022. The net loss of the company was US$334.6 million in FY2023, compared to a net loss of US$443.3 million in FY2022.

For a complete picture of Odronextamab’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.