Ofranergene obadenovec is under clinical development by Vascular Biogenics and currently in the Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Ofranergene obadenovec’s likelihood of approval (LoA) and phase transition for Peritoneal Cancer took place on 17 Nov 2021, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway and decreased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Ofranergene obadenovec Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Ofranergene obadenovec overview

Ofranergene obadenovec (VB-111) is under development for the treatment of advanced metastatic cancer, recurrent glioblastoma multiforme (rGBM), melanoma, metastatic lung cancer, thyroid cancer, metastatic gastrointestinal cancer, colon cancer, peritoneal cancer, fallopian tube cancer, uterine papillary serous carcinomas, metastatic colorectal cancer, glioblastoma, gliosarcoma and gynecologic malignant mixed Mullerian tumors. It is administered as an intravenous infusion. The drug candidate is a next generation anti-angiogenesis therapy based on vascular targeting system (VTS) technology. The drug candidate was also under development for the treatment of renal cell carcinoma, neuroendocrine tumors, epithelial ovarian cancer and metastatic lung cancer.

Vascular Biogenics overview

Vascular Biogenics, dba VBL Therapeutics, is a biopharmaceutical company. It discovers, develops and commercializes gene-therapy medicines for the treatment of cancer and inflammatory diseases. The company’s lead product candidate VB-111, a gene-based biologic agent is developed to treat recurrent glioblastoma, colon, ovarian, thyroid cancer and solid tumors. Its pipeline products include VB 201 and VB 703, oral small molecules being developed through lecinoxoids platform for treating cardiovascular diseases, liver and renal fibrosis. Vascular Biogenics uses its proprietary vascular targeting system technology to enable systemic administration of gene therapy and improve angiogenic blood vessels. The company is investigating its VB-600 platform targeting MOSPD2 for treating cancers and inflammatory diseases. Vascular Biogenics is headquartered in Modiin, Tel Aviv, Israel.

Quick View Ofranergene obadenovec LOA Data

Report Segments
  • Innovator
Drug Name
  • Ofranergene obadenovec
Administration Pathway
  • Intravenous
Therapeutic Areas
  • Oncology
Key Developers
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.