Pamrevlumab is under clinical development by FibroGen and currently in Phase III for Metastatic Pancreatic Cancer. According to GlobalData, Phase III drugs for Metastatic Pancreatic Cancer have a 29% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Pamrevlumab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Pamrevlumab overview
Pamrevlumab (FG-3019) is under development for the treatment of metastatic pancreatic ductal adenocarcinoma (PDAC) or fibrosis involved in pancreatic cancer, liver fibrosis and coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is administered as an intravenous infusion. FG-3019 is a fully human recombinant IgG, kappa monoclonal antibody that acts against connective tissue growth factor (CTGF). The drug candidate was also under development for the treatment of systemic sclerosis, microalbuminuria, pneumonia, focal segmental glomerulosclerosis, type I or type II diabetes mellitus, diabetic nephropathy, (diabetic kidney disease) and proteinuria.
It was under development for the treatment of idiopathic pulmonary fibrosis, Duchenne Muscular dystrophy.
FibroGen overview
FibroGen is a biopharmaceutical company that discovers, and develops medicines for the treatment of anemia, cancer, and fibrotic disease. Its approved product includes roxadustat for the treatment of treatment of anemia associated with chronic kidney disease, in both dialysis-dependent (DD) and non-dialysis-dependent (NDD) patients. Its pipeline product includes pamrevlumab (FG-3019) for the treatment of idiopathic pulmonary fibrosis (IPF) and duchenne muscular dystrophy (DMD). The company has operations in the US, Hong Kong, Finland, Cayman Islands and China. FibroGen is headquartered in San Francisco, California, the US.
For a complete picture of Pamrevlumab’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
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Premium Insights Likelihood of Approval and Phase Transition Success Rate Model - Pamrevlumab in Metastatic Pancreatic Cancer
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