Pepinemab is under clinical development by Vaccinex and currently in the Phase I and Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Pepinemab’s likelihood of approval (LoA) and phase transition for Solid Tumor took place on 27 Jun 2022, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Pepinemab Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Pepinemab overview

Pepinemab (VX-15) is under development for the treatment of multiple sclerosis (MS), Huntington's disease, metastatic adenocarcinoma of the pancreas, metastatic melanoma, recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC), non-small cell lung cancer, Alzheimer's disease, osteosarcoma, squamous cell carcinoma of the head and neck, oropharyngeal cancer, oral cavity cancer, laryngeal cancer, rett syndrome, relapsed/refractory solid tumors such as metastatic colorectal, breast, papillary thyroid cancer, pancreatic ductal adenocarcinoma and pediatric patients with solid tumors. It is administered intravenously. The drug candidate is a monoclonal antibody targeting semaphorin 4D (SEMA4D). The drug candidate is developed based on proprietary ActivMab technology, which involves a vaccinia virus-based vector to express antibodies in mammalian cells. It was also under development for the treatment of melanoma.

Vaccinex overview

Vaccinex is a clinical-stage biotechnology company. It discovers and develops targeted biotherapeutics to treat neurodegenerative diseases, cancer and autoimmune disorders. The company’s lead platform technologies include antibody platform and ActivMAb, SEMA4D, and antibody discovery platform. Vaccinex through its antibody platform develops its lead product candidate VX15, for the treatment of various indications such as neurodegenerative diseases, neuroinflammatory, and cancer. The company also develops VX5 that is in preclinical development for the treatment of autoimmune disorders. It has partnership with biotechnology and biopharmaceutical companies to enhance its product candidates. Vaccinex is headquartered in Rochester, New York, the US.

Quick View Pepinemab LOA Data

Report Segments
  • Innovator
Drug Name
  • Pepinemab
Administration Pathway
  • Intravenous
Therapeutic Areas
  • Central Nervous System
  • Oncology
Key Developers
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.