Plocabulin is under clinical development by Pharma Mar and currently in the Phase I and Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Plocabulin’s likelihood of approval (LoA) and phase transition for Solid Tumor took place on 27 Jun 2022, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway and decreased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Plocabulin Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Plocabulin overview

Plocabulin (PM-184, PM-060184) is under development for the treatment of refractory advanced solid tumors including advanced gastrointestinal stromal tumor (GIST), biliary tract adenocarcinoma, thymic cancer, cervix carcinoma, epithelial ovarian cancer including primary peritoneal disease, fallopian tube carcinomas, endometrial adenocarcinomas, advanced or metastatic head and neck cancer, non-small cell lung cancer (NSCLC), germ cell tumors (GCTs), biliary tract adenocarcinoma, urothelial cancer and HER2 negative metastatic breast cancer (second line) and metastatic colorectal cancer. The drug candidate is administered. It is a marine sponge (Lithoplocamia lithistoides) derived, synthetically produced compound. It is a tubulin-binding agent. The drug candidate was under development for the treatment of hormone-receptor positive advanced breast cancer.

Pharma Mar overview

Pharma Mar discovers, develops and markets marine-derived drugs to treat cancer. The company’s marketed products include Yondelis (trabectedin) an antitumor agent indicated for the treatment of soft tissue sarcoma and relapsed ovarian cancer in combination with doxorubicin HCl liposome injection; Aplidin (plitidepsin), an anticancer agent for the treatment of multiple myeloma; and Zepzelca (lurbinectedin) for small cell lung cancer. Pharma Mar offers in vitro diagnostic products used for detection of virus and bacteria in respiratory infections and human papilloma virus genotypes, among others. Pharma Mar also offers kits used for diagnosis of SARS-CoV-2, influenza A and B and respiratory syncytial virus. Its development pipeline includes PM14 for solid tumors, among others. It also develops RNAi candidates for the treatment of retina diseases. The company has subsidiaries in Germany, Italy, France, Switzerland, the UK, and the US, among others. Pharma Mar is headquartered in Madrid, Spain.

Quick View Plocabulin LOA Data

Report Segments
  • Innovator
Drug Name
  • Plocabulin
Administration Pathway
  • Intravenous
Therapeutic Areas
  • Oncology
Key Developers
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.