PMUC1CALLO-1 is a gene-modified cell therapy commercialized by Poseida Therapeutics, with a leading Phase I program in Kidney Cancer (Renal Cell Cancer). According to Globaldata, it is involved in 1 clinical trial, which is ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of PMUC1CALLO-1’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for PMUC1CALLO-1 is expected to reach an annual total of $8 mn by 2038 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

PMUC1CALLO-1 Overview

P-MUC1CALLO-1 is under development for the treatment of solid tumors derived from epithelial cells tumors including triple-negative breast cancer, renal cancer, ovarian cancer, non-small cell lung cancer, esophageal cancer, gastric cancer, pancreatic cancer and colorectal cancers. The drug candidate is administered through intravenous route. It comprises of allogeneic stem memory T cells (Tscm), genetically engineered to express chimeric antigen receptor (CAR). It acts by targeting the cells expressing mucin1. The therapeutic candidate is being developed based on Piggybac DNA modification system and CAS Clover gene-editing technology.

Poseida Therapeutics Overview

Poseida Therapeutics is a biopharmaceutical company. It utilizes proprietary gene engineering platform, to develop cell and gene therapies to treat solid tumors and hematological malignancies. The company’s product pipeline include P-PSMA-ALL01 for treatmane of solid tumors; and other drug programs such as P-BCMA-ALL01, P-BCMACD19-ALL01, P-CD19CD20-ALL01, and P-CD70=ALL01 to treat heme malignancies. Poseida Therapeutics is also investigating P-OTC-101, P-FVIII-101, and P-PAH-101 programs for liver diseases. The company works in collaboration with Roche. Poseida Therapeutics is headquartered in San Diego, California, the US.
The company reported revenues of (US Dollars) US$130.5 million for the fiscal year ended December 2022 (FY2022), compared to a revenue of US$31.2 million in FY2021. The operating loss of the company was US$60 million in FY2022, compared to an operating loss of US$121.9 million in FY2021. The net loss of the company was US$64 million in FY2022, compared to a net loss of US$125 million in FY2021. The company reported revenues of US$20 million for the second quarter ended June 2023, an increase of 93.5% over the previous quarter.

For a complete picture of PMUC1CALLO-1’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 20 February 2024

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To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.