Prasinezumab is a Monoclonal Antibody owned by Prothena Corp, and is involved in 5 clinical trials, of which 4 were completed, and 1 is ongoing.

Prasinezumab is an alpha-synuclein monoclonal antibody. Alpha-synuclein normally in an unstructured soluble form found almost exclusively in the nucleus of brain neurons. Alpha-synuclein is involved in neuronal plasticity and could act as a molecular chaperone. In synucleinopathies, the synuclein protein misfolds and aggregates to form insoluble fibrils that contribute to the pathology of the disease. Antibodies targeting alpha-synuclein might slow down or reduce the neurodegeneration associated with synuclein misfolding and/or transmission.

The revenue for Prasinezumab is expected to reach a total of $346m through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Prasinezumab NPV Report.

Prasinezumab was originated by Prothena Biosciences and is currently owned by Prothena Corp. F. Hoffmann-La Roche is the other company associated in development or marketing of Prasinezumab.

Prasinezumab Overview

Prasinezumab is under development for the treatment of Parkinson’s disease (PD) and other synucleinopathies. It is administered through intravenous route as an infusion. The drug candidate is a monoclonal antibody targeting alpha-synuclein. It is a new molecular entity (NME).

F. Hoffmann-La Roche Overview

F. Hoffmann-La Roche (Roche) is a biotechnology company that develops drugs and diagnostics to treat major diseases. It provides medicines for the treatment of cancer, other auto-immune diseases, central nervous system disorders, ophthalmological disorders, infectious diseases, and respiratory diseases. The company also offers in vitro diagnostics, tissue-based cancer diagnostics, and diabetes management solutions. Roche conducts research to identify novel methods to prevent, diagnose, and treat diseases. The company offers its products and services to hospitals, commercial laboratories, healthcare professionals, researchers, and pharmacists. Together with its subsidiaries and partners, the company has operations in various countries. Roche is headquartered in Basel, Switzerland.

The company reported revenues of (Swiss Francs) CHF62,801 million for the fiscal year ended December 2021 (FY2021), an increase of 7.7% over FY2020. In FY2021, the company’s operating margin was 28.9%, compared to an operating margin of 31.8% in FY2020. In FY2021, the company recorded a net margin of 22.2%, compared to a net margin of 24.5% in FY2020.

Quick View – Prasinezumab

Report Segments
  • Innovator
Drug Name
  • Prasinezumab
Administration Pathway
  • Intravenous
Therapeutic Areas
  • Central Nervous System
Key Companies
  • Sponsor Company: Prothena Corp
  • Originator: Prothena Biosciences
Highest Development Stage
  • Phase II


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.