PRI-724 is under clinical development by PRISM Pharma and currently in the Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.
According to GlobalData, the latest event to affect PRI-724’s likelihood of approval (LoA) and phase transition for Solid Tumor took place on 30 Jul 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.
GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their PRI-724 Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.
PRI-724 (OP-724) is under development for the treatment of HCV or HBV-induced liver cirrhosis, leukemia such as acute myeloid leukemia (AML), neuroendocrine tumors, chronic myeloid leukemia (CML), metastatic colorectal cancer, retinal fibrosis, primary biliary cholangitis, idiopathic pulmonary fibrosis, gastrointestinal tumors such as small bowel carcinoma and gastrointestinal neuroendocrine tumors, desmoid tumors, anaplastic thyroid cancer (ATC), endometrial cancer, melanoma, myelodysplastic syndrome, colorectal cancer (CRC), hepatocellular carcinoma (HCC), pancreatic cancer, prostate cancer and ovarian cancer. The drug candidate is administered through intravenous and oral route. PRI-724 is a new chemical entity. It acts by targeting CBP/beta-catenin complex formation, and modulates the beta-catenin dependent pathway of Wnt signaling to provide a selective cell anti-proliferative effect. PRI-724 is generated by using the PRISM’s proprietary optimization technology. It was also under development for the treatment of choroidal neovascularization, proliferative vitreoretinopathy (PVR), hematological cancer, colorectal cancer (third line therapy), advanced or metastatic pancreatic adenocarcinoma and metastatic colorectal cancer (first line therapy).
PRISM Pharma overview
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