PRT-3645 is under clinical development by Prelude Therapeutics and currently in Phase I for Oral Cavity (Mouth) Cancer. According to GlobalData, Phase I drugs for Oral Cavity (Mouth) Cancer does not have sufficient historical data to build an indication benchmark PTSR for Phase I. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the PRT-3645 LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
PRT-3645 overview
PRT-3645 is under development for the treatment of solid tumor including recurrent glioblastoma, HER2-negative breast cancer, HER2 positive breast cancer, astrocytoma, malignant mesothelioma, HPV-negative HNSCC (including oral cavity, oropharynx, hypopharynx, and larynx), sarcoma, endometrial cancer, colorectal cancer and non-small cell lung cancer. The drug candidate acts by targeting CDK4 and CDK6. It is administered through oral route as capsules.
It was under development for melanoma.
Prelude Therapeutics overview
Prelude Therapeutics (Prelude) is a clinical-stage oncology company that provides drug discovery and development for the treatment of cancers. The company pipeline products include PRT3789, PRT2527 and PRT3645 for the indication including solid Tumors, and Heme Malignancies. Its other pipelines include pipeline includes an IV-administered, potent and highly selective SMARCA2 degrader, PRT3789, a preclinical oral SMARCA2 selective degrader, PRT7732, a potent and highly selective CDK9 inhibitor, PRT2527, and a next-generation CDK4/6 inhibitor, PRT3645. The company collaborates with AbCellera Biologics. on an early-stage discovery program. Prelude is headquartered in Wilmington, Delaware, the US.
For a complete picture of PRT-3645’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
