Ragifilimab is under clinical development by Incyte and currently in Phase II for Recurrent Head And Neck Cancer Squamous Cell Carcinoma. According to GlobalData, Phase II drugs for Recurrent Head And Neck Cancer Squamous Cell Carcinoma have a 37% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Ragifilimab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
INCAGN-1876 is under development for advanced or metastatic solid tumors such as recurrent glioblastoma multiforme and relapsed melanoma, metastatic cervical cancer, gastric cancer including stomach, esophageal, and adenocarcinoma of gastroesophageal Junction (GEJ), squamous cell carcinoma of the head and neck (SCCHN), oral cavity (mouth) cancer, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer. It is administered intravenously as a solution concentrate. It is a monoclonal antibody targeting GITR (glucocorticoid induced tumor necrosis factor receptor). The drug candidate is based on the retrocyte display technology. It was also under development for hematological malignancies, metaststic melanoma,metastatic adenocarcinoma of endometrium, non-small cell lung cancer, urothelial carcinoma and renal cell carcinoma.
Incyte is a biopharmaceutical company, which discovers, develops and commercializes proprietary cancer therapeutics. The company’s lead product, Jakafi (ruxolitinib) is marketed in the US for the treatment of patients with high-risk myelofibrosis; and polycythemia vera who are intolerant to hydroxyurea. The company distributes Jakafi through a network of specialty pharmacy providers and wholesalers. In collaboration with Incyte, Novartis International Pharmaceutical Ltd (Novartis) develops and commercializes ruxolitinib outside the US for hematologic and cancer indications under the name Jakavi. The company’s pipeline portfolio encompasses drugs for the treatment of lung cancer, graft versus host disease, non-small cell lung cancer, b-cell malignancies, solid tumors, glioblastoma, liver cancer, and advanced malignancies. Incyte is headquartered in Wilmington, Delaware, the US.
For a complete picture of Ragifilimab’s drug-specific PTSR and LoA scores, buy the report here.