RBX-7455 is under clinical development by Rebiotix and currently in Phase II for Hepatic Encephalopathy. According to GlobalData, Phase II drugs for Hepatic Encephalopathy have a 30% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how RBX-7455’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

RBX-7455 overview

RBX-7455 is under development for the prevention of Clostridium difficile infections, hepatic encephalopathy and Crohn's disease. The drug candidate is administered through oral route as a capsule. It constitutes fecal microbiota suspension which contains live microbes. The therapeutic candidate is developed based on microbial restoration therapy (MRT) platform.

Rebiotix overview

Rebiotix a subsidiary of Ferring Holding SA, is a clinical stage biotechnology company that develops treatments for debilitating diseases. The company’s pipeline products include RBX2660, RBX7455. Its RBX2660 is available in the form of enema formulation used for the treatment recurrent clostridium difficile infection. Rebiotix’s RBX7455 is an oral formulation in a lyophilized form. The company partners with physicians to evaluate the use of Microbiota Restoration Therapy (MRT) for ulcerative colitis, crohn’s disease, chronic idiopathic constipation, myoclonus dystonia, autism, urea cycle disorders, chronic fatigue syndrome hepatic encephalopathy and multi drug-resistant organisms. Rebiotix is headquartered in Roseville, Minnesota, the US.

For a complete picture of RBX-7455’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 2 September 2023

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.