Relatlimab is a Monoclonal Antibody owned by Bristol-Myers Squibb, and is involved in 34 clinical trials, of which 5 were completed, and 29 are ongoing.
Relatlimab (BMS-986016) binds to LAG-3 on tumor infiltrating lymphocytes (TILs). This activates antigen-specific T-lymphocytes and enhances cytotoxic T cell-mediated tumor cell lysis, which would lead to a reduction in tumor growth. LAG-3 is a member of the immunoglobulin superfamily (IgSF) and binds to major histocompatibility complex (MHC) class II. The LAG-3 expression on TILs is associated with tumor-mediated immune suppression.
The revenue for Relatlimab is expected to reach a total of $343m through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Relatlimab NPV Report.
Relatlimab (BMS-986016) is under development for the treatment of hematological malignancies, renal medullary carcinoma (RMC), newly diagnosed older acute myeloid leukemia, metastatic hepatocellular carcinoma (HCC), advanced unresectable or metastatic basal cell carcinoma, relapsed and refractory acute myeloid leukemia, non-Hodgkin lymphoma, relapsed refractory multiple myeloma, Hodgkin lymphoma, diffuse large B-cell lymphoma, chronic lymphocytic leukemia (CLL), melanoma, multiple myeloma, gastric cancer, soft tissue sarcoma recurrent head and neck squamous cell carcinoma, non-small cell lung cancer, cervical cancer, ovarian cancer, bladder cancer, renal cell carcinoma, hepatocellular cancer, recurrent glioblastoma multiforme, gliosarcoma, colorectal cancer (solid tumors) and metastatic or unresectable melanoma (first line therapy). It is administered intravenously. It is a monoclonal antibody directed against the inhibitor receptor lymphocyte activation gene-3 (LAG-3), with potential immunomodulating and antineoplastic activities.
It was under development for solid tumors in Japan.
Ono Pharmaceutical Overview
Ono Pharmaceutical focuses on the research, development, manufacture and sale of prescription pharmaceuticals and diagnostic reagents. Its product portfolio includes medicines for the treatment of type II diabetes, overactive bladder, osteoporosis, cancer, chemotherapy-induced nausea and vomiting, osteoporosis, Alzheimer’s disease, peripheral circulatory disorder, bronchial asthma and allergic rhinitis, among others. The company offers products in various formulations such as capsules, tablets, injections, patches, dry syrup and intravenous infusions. Ono Pharmaceutical has three manufacturing facilities; Joto Product Development Center, Yamaguchi Plant, and Fujiyama Plant. It offers products in the Americas, Europe, and Asia. Ono Pharmaceutical is headquartered in Osaka, Japan.
The company reported revenues of (Yen) JPY361,361 million for the fiscal year ended March 2022 (FY2022), an increase of 16.8% over FY2021. In FY2022, the company’s operating margin was 28.6%, compared to an operating margin of 31.8% in FY2021. In FY2022, the company recorded a net margin of 22.3%, compared to a net margin of 24.4% in FY2021. The company reported revenues of JPY109,979 million for the second quarter ended September 2022, an increase of 3.1% over the previous quarter.
Quick View – Relatlimab
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