Rilimogene galvacirepvec is under clinical development by Bavarian Nordic and currently in the Phase I and Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Rilimogene galvacirepvec’s likelihood of approval (LoA) and phase transition for Hormone-Sensitive Prostate Cancer took place on 13 Jan 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Rilimogene galvacirepvec Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Rilimogene galvacirepvec overview

Rilimogene galvacirepvec (Prostvac) is under development for the treatment of metastatic hormone-sensitive prostate cancer and castration-resistant and non-metastatic prostate cancer. It was also under development for metastatic castration-resistant prostate cancer. It is administered through subcutaneous route. It is sequentially dosed as a combination of two different pox viruses (Prostvac-V and Prostvac-F) which each encode prostate-specific antigen (PSA) plus three co-stimulatory molecule transgenes B7.1, ICAM-1, and LFA-3, known collectively as Tricom. The vaccine candidate is developed based on PSA-Tricom, poxvirus-based (vaccinia-fowl pox-Tricom) technology platform.

Bavarian Nordic overview

Bavarian Nordic is a vaccine company that develops, manufactures and commercializes vaccines for the prevention of life-threating diseases. The company develops its products using poxvirus-based technology platforms including modified vaccinia Ankara –Bavarian Nordic (MVA-BN). The company’s marketed products include JYNNEOS for smallpox and monkeypox; Encepur for tick-borne encephalitis; MVABEA for ebola; and Rabipur/RabAvert for rabbies. Its pipeline products are intended for the treatment of smallpox, respiratory syncytial virus, COVID-19, HER2- and brachyury-expressing cancers and Ebola infections. Bavarian Nordic has collaboration with the US government and various institutes, to develop its product candidates for the treatment of cancer and infectious diseases. It has a presence in the US, Denmark, Switzerland and Germany. Bavarian Nordic is headquartered in Hellerup, Denmark.

Quick View Rilimogene galvacirepvec LOA Data

Report Segments
  • Innovator
Drug Name
  • Rilimogene galvacirepvec
Administration Pathway
  • Subcutaneous
Therapeutic Areas
  • Oncology
Key Developers
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.