Sirolimus is under clinical development by OrphAI Therapeutics and currently in Phase II for Bronchiolitis Obliterans. According to GlobalData, Phase II drugs for Bronchiolitis Obliterans does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Sirolimus LoA Report. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Sirolimus overview

Sirolimus is under development for the treatment of bronchiolitis obliterans post lung transplant and pulmonary sarcoidosis. The drug candidate is administered through inhalational route. It targets mammalian target of rapamycin (mTOR). It is being developed artificial intelligence based Guardian Angel Platform.

The drug candidate was also under development for the treatment of lymphangioleiomyomatosis (LAM), tuberous sclerosis complex and pulmonary arterial hypertension.

OrphAI Therapeutics overview

OrphAI Therapeutics (OrphAI), formerly AI Therapeutics Inc, is a biopharmaceutical company that identifies and develops treatments for neurological diseases and cancers. It investigates LAM-001 program against pulmonary sarcoidosis and bronchiolitis obliterans disease caused after lung transplantation resulting in obstruction of the smallest airways of the lungs. The company is also evaluating AIT–101 drugs to treat amyotrophic lateral sclerosis and AIT-102 for rare diseases. OrphAI is headquartered in Guilford, Connecticut, the US.

For a complete picture of Sirolimus’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

Data Insights


The gold standard of business intelligence.

Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.