SRK-181 is under clinical development by Scholar Rock and currently in Phase I for Solid Tumor. According to GlobalData, Phase I drugs for Solid Tumor have a 54% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how SRK-181’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
SRK-181 is under development for the treatment of solid tumors including but not limited to bladder cancer, myelofibrosis, urothelial cancer, non-small cell lung cancer, melanoma, clear cell renal cell carcinoma (ccRCC), myelofibrosis , breast cancer and ovarian cancer and oropharyngeal cancer. It acts by targeting transforming growth factor beta 1 (TGFB1). The drug candidate is developed using the supracellular activation technology platform.
Scholar Rock overview
Scholar Rock, a subsidiary of Scholar Rock Holding Corp, operates as a biopharmaceutical company that discovers and develops novel medicines for serious diseases. Its proprietary technology platform develops new medicines, modulating supracellular activation, for the application in the treatment of fibrosis, diseases of musculoskeletal systems, and autoimmune diseases. Scholar Rock’s lead product candidate include SRK-015, a selective inhibitor which activates latent myostatin in skeletal muscle used for the treatment of spinal muscular atrophy (SMA). The company is creating a pipeline of novel product candidates for a wide range of serious diseases such as neuromuscular disorders, cancer, fibrosis, and anemia. It collaborates with various biotechnology companies for the development of its pipeline products. Scholar Rock is headquartered in Cambridge, Massachusetts, the US.
For a complete picture of SRK-181’s drug-specific PTSR and LoA scores, buy the report here.