TAC-101 is under clinical development by Triumvira Immunologics and currently in Phase II for Bile Duct Cancer (Cholangiocarcinoma). According to GlobalData, Phase II drugs for Bile Duct Cancer (Cholangiocarcinoma) have a 30% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how TAC-101’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

TAC-101 overview

TAC-101 is under development for the treatment of solid tumor include gastric, GEJ, esophageal adenocarcinoma, PDAC, colorectal cancer, cholangiocarcinoma, ovarian mucinous cancer, gallbladder cancer and NSCLC.. The therapeutic candidate comprises autologous T-cells which are engineered to express T cell Antigen Coupler (TAC) complex targeting claudin 18.2 expressing tumor cells. It is being developed based on T-cell antigen coupler (TAC) technology.  It is administered through intravenous route.

Triumvira Immunologics overview

Triumvira Immunologics (Triumvira) is a biopharmaceutical company that develops novel cancer therapies. The company uses chimeric antigen receptors and engineered T-cell receptors for the development of therapies. Triumvira is involved in the investigation of the mechanism in which TAC directs the engineered T-cells to target antigens and activates the T-cells after binding with antigen. The company’s product pipeline includes TAC01-HER2 and TAC02-HER2 for autologous and allogenic solid tumors which are in the initial stages of development. It operates a research facility in Hamilton, Ontario, Canada. Triumvira is headquartered in Austin, Texas, the US.

For a complete picture of TAC-101’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.