Taladegib is under clinical development by F. Hoffmann-La Roche and currently in Phase II for Esophageal Cancer. According to GlobalData, Phase II drugs for Esophageal Cancer have a 27% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Taladegib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Taladegib (LY-2940680) is under development for the treatment of advanced cancers including epithelial ovarian, fallopian tube or primary peritoneal cancer and adenocarcinoma of the esophagus or gastroesophageal junction, idiopathic pulmonary fibrosis (IPF) and advanced solid tumors harboring PTCH1 loss of function mutations. The drug candidate targets smoothened (SMO) receptor. The drug candidate is administered through oral route. It was also under development for small cell lung cancer, recurrent or refractory rhabdomyosarcoma, refractory medulloblastoma and as a topical formulation for superficial and nodular basal cell carcinoma.
F. Hoffmann-La Roche overview
F. Hoffmann-La Roche (Roche) is a biotechnology company that develops drugs and diagnostics to treat major diseases. It provides medicines for the treatment of cancer, other auto-immune diseases, central nervous system disorders, ophthalmological disorders, infectious diseases, and respiratory diseases. The company also offers in vitro diagnostics, tissue-based cancer diagnostics, and diabetes management solutions. Roche conducts research to identify novel methods to prevent, diagnose, and treat diseases. The company offers its products and services to hospitals, commercial laboratories, healthcare professionals, researchers, and pharmacists. Together with its subsidiaries and partners, the company has operations in various countries. Roche is headquartered in Basel, Switzerland.
For a complete picture of Taladegib’s drug-specific PTSR and LoA scores, buy the report here.