TH-104 is under clinical development by Tharimmune and currently in Phase I for Pruritus. According to GlobalData, Phase I drugs for Pruritus have an 85% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how TH-104’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
TH-104 overview
Nalmefene (AV-104) is under development for the treatment of pruritus associated with chronic liver disease, cholestatic liver disease, atopic dermatitis (eczema), primary biliary cholangitis (PBC) and undisclosed indication. It is administered through the buccal route in the form of film. It is being developed based on speedit transmucosal film technology. It acts by targeting kappa Type opioid receptor, Mu-type opioid receptor and interleukin 17.
Tharimmune overview
Tharimmune, formerly Hillstream BioPharma, is a biotechnology company that develops novel small molecule therapeutics for cancer treatments. Its novel therapeutic candidates target ferroptosis, an emerging new anti-cancer mechanism resulting in iron-mediated cell death (IMCD) and targeted immuno-oncology novel biologics, for the treatment of drug-resistant cancers. Tharimmune product pipeline includes TH104, TH3215, TH0059 and TH1940. The company develops a portfolio of therapeutic candidates for rare, inflammatory, and oncologic diseases. Tharimmune is headquartered in Bridgewater, New Jersey, the US.
For a complete picture of TH-104’s drug-specific PTSR and LoA scores, buy the report here.
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