TmGPC2 01 CAR-T is under clinical development by Kite Pharma and currently in Phase I for Neuroblastoma. According to GlobalData, Phase I drugs for Neuroblastoma have an 85% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how TmGPC2 01 CAR-T’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

TmGPC2 01 CAR-T overview

The therapeutic candidate is under development for the treatment of neuroblastoma, small cell lung cancer (SCLC), neuroendocrine tumor. It comprises of lentiviral transduced GPC2- targeting chimeric antigen receptor-modified T (CAR T) cells.

It was also under development for the treatment of bladder cancer.

Kite Pharma overview

Kite Pharma, a subsidiary of Gilead Sciences Inc, is a biopharmaceutical company that discovers and develops cancer immunotherapy products. Kite Pharma provides products like Chimeric Antigen Receptors(CAR), KTE-C19 DLBCL, PMBCL, TFL (ZUMA-1); Chemo Refractory Diffuse Large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma (PMBCL), transformed follicular lymphoma (TFL), KTE-C19 MCL (ZUMA-2); Relapsed/Refractory Mantle Cell Lymphoma (MCL), KTE-C19 Adult and Pediatric ALL (ZUMA-3, ZUMA-4); Acute Lymphoblastic Leukemia (ALL), Axicabtagene ciloleucel; 2L+ high-risk follicular lymphoma, Axicabtagene ciloleucel; 1L high-risk large B-cell lymphoma, Axicabtagene ciloleucel; 2L large B-cell lymphoma outpatient, Brexucabtagene autoleucel; Basket (rare B-cell malignancies). It carries out the Kite External Research Program service. It works in collaboration with various institutes and companies. The company has an operational presence in the UK, Netherlands and the US. Kite Pharma is headquartered in Santa Monica, California, the US.

For a complete picture of TmGPC2 01 CAR-T’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.