TXA-127 is under clinical development by Constant Therapeutics and currently in Phase II for Dilated Cardiomyopathy. According to GlobalData, Phase II drugs for Dilated Cardiomyopathy have a 50% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how TXA-127’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

TXA-127 overview

TXA-127 is under development for the treatment of marfan syndrome, diabetes, amyotrophic lateral sclerosis (ALS), dystrophic epidermolysis bullosa (DEB), laminin-deficient congenital muscular dystrophy (LAMA), Limb-girdle muscular dystrophy (LGMD),  ischemic stroke, DMD-associated dilated cardiomyopathy and coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome causing coronavirus 2 (SARS-CoV-2). It is administered through oral, parenteral subcutaneous and intravenous route. It is a naturally occurring peptide Angiotensin (1-7). It is developed based on the Peptelligence platform that comprises peptide oral drug delivery for the enhanced delivery of TXA-127. It was also under development for chemotherapy induced thrombocytopenia, HIV, double cord stem cell engraftment, pulmonary arterial hypertension, peripheral vascular disease, myelodysplastic syndrome, hematopoietic stem cell transplantation, coronavirus disease 2019 (covid-19) associated acute respiratory distress syndrome and Duchenne muscular dystrophy (DMD).

Constant Therapeutics overview

Constant Therapeutics is a biopharmaceutical company that develops drugs that target the alternative renin-angiotensin system, the protective arm of the renin-angiotensin system, and also develops Mas receptor agonists for the treatment of COVID-19, CNS, and rare disorders. Constant Therapeutics is headquartered in Boston, Massachusetts, the US.

For a complete picture of TXA-127’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.