Vactosertib is under clinical development by MedPacto and currently in Phase II for Metastatic Transitional (Urothelial) Tract Cancer. According to GlobalData, Phase II drugs for Metastatic Transitional (Urothelial) Tract Cancer have a 47% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Vactosertib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Vactosertib overview

Vactosertib (TEW-7197) is under development for the treatment of advanced solid tumors including melanoma, breast cancer, hepatocellular carcinoma, metastatic non-small cell lung cancer, prostate cancer, chronic myelocytic leukemia, myelodysplastic syndrome, metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma, adenocarcinoma of the gastroesophageal junction, glioblastoma multiforme, gastric cancer, pancreatic cancer, desmoid sarcoma, metastatic urothelial bladder carcinoma including renal pelvis cancer, ureters cancer, urinary bladder cancer, refractory acute myeloid leukemia, relapsed acute myeloid leukemia, acute lymphoblastic lymphoma, non-Hodgkin lymphoma, Hodgkin lymphoma and urethral cancer, myeloproliferative neoplasm and colon cancer. The drug candidate is administered orally as a tablet. It acts by inhibiting protein serine/threonine kinase activity of transforming growth factor (TGF)-beta receptor type 1 (TGFBR1, ALK5). It was also under development for refractory and relapsed multiple myeloma, hepatic fibrosis, renal fibrosis, pulmonary fibrosis.

MedPacto overview

MedPacto, a subsidiary of Theragen Etex Co Ltd, is a biotechnology company that discovers and develops therapies to treat cancer and autoimmune diseases. Its product pipeline includes Vactosertib drug, to treat gastric and pancreatic cancer, desmoid sarcoma, colorectal and bladder cancer, non-small cell lung carcinoma (NSCLC), multiple myeloma and myeloproliferative neoplasms. The company is also investigating MA-B2, MPD-001, MPD-002 and MPD-003 against solid tumors; MU-D201, to treat diffuse large B-cell lymphoma (DLBCL); and also MI-S4 for nonalcoholic steatohepatitis (NASH). It works in partnership with pharmaceutical companies including Merck and AstraZeneca Plc. MedPacto is headquartered in Seoul, South Korea.

For a complete picture of Vactosertib’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.