Vactosertib is under clinical development by MedPacto and currently in Phase II for Colorectal Cancer. According to GlobalData, Phase II drugs for Colorectal Cancer have a 25% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Vactosertib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Vactosertib overview
Vactosertib (TEW-7197) is under development for the treatment of advanced solid tumors including melanoma, breast cancer, hepatocellular carcinoma, metastatic non-small cell lung cancer, prostate cancer, chronic myelocytic leukemia, myelodysplastic syndrome, metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma, adenocarcinoma of the gastroesophageal junction, glioblastoma multiforme, gastric cancer, pancreatic cancer, desmoid sarcoma, metastatic urothelial bladder carcinoma including renal pelvis cancer, ureters cancer, urinary bladder cancer, refractory acute myeloid leukemia, relapsed acute myeloid leukemia, acute lymphoblastic lymphoma, non-Hodgkin lymphoma, Hodgkin lymphoma and urethral cancer, myeloproliferative neoplasm and colon cancer. The drug candidate is administered orally as a tablet. It acts by inhibiting protein serine/threonine kinase activity of transforming growth factor (TGF)-beta receptor type 1 (TGFBR1, ALK5). It was also under development for refractory and relapsed multiple myeloma, hepatic fibrosis, renal fibrosis, pulmonary fibrosis.
For a complete picture of Vactosertib’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
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Premium Insights Likelihood of Approval and Phase Transition Success Rate Model - Vactosertib in Colorectal Cancer
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