Vamikibart is under clinical development by CTx Operations and currently in Phase II for Diabetic Macular Edema. According to GlobalData, Phase II drugs for Diabetic Macular Edema have a 46% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Vamikibart’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Vamikibart overview

Vamikibart is under development for the treatment of diabetic macular edema (DME) and uveitic macular edema (UME). The drug candidate is administered through intravitreal route. It is a humanized monoclonal antibody targeting interleukin-6. It is developed based on AMP-Rx protein engineering technology.

CTx Operations overview

CTx Operations, Inc (CTx Operations), formerly Carisma Therapeutics Inc, is a biotechnology service provider that discovers and develops macrophage-based immunotherapeutic for the treatment of cancer. The company product CAR-macrophage platform to provide human macrophages the capability to identify relevant targets to exterminate cancer cells in solid tumors. CTx Operations technology harnesses the latest developments in macrophage biology, chimeric antigen receptor engineering and adoptive cellular therapy to treat multiple diseases in humans. Its portfolio includes CT – 0508 (HER2), CT – 1119 (Mesothelin), CT – 0729 (PSMA) which treat mesothelin-positive solid tumors, prostate cancer, neurodegeneration, liver fibrosis and others. It is a subsidiary of Carisma Therapeutics Inc. CTx Operations is headquartered in Philadelphia, Pennsylvania, the US.

For a complete picture of Vamikibart’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 7 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.