Isolation of aseptic processes is not a new technology. Rigid stainless-steel isolators have been available...
Patch pump therapy is a convenient way of drug administration. The devices can be worn directly on the body, no tubing has to be attached and the cannula or needle is inserted automatically.
Patch pumps are often equipped with programmable delivery patterns, which allow high flexibility and rational adjustment to the patient’s needs. In turn, the devices must fulfil some of the highest criteria in dosage accuracy and safety.
The fluidic path through the whole device, including body resistance at the injection site, combined with the physical properties of the drug defines the pressure loss that the pump needs to overcome. Since smaller needles are more comfortable and therefore preferred, they often represent the bottleneck of the system. The dependencies thereof are depicted hereafter.