Troubleshooting Tablet Defects in No Time
There are numerous tablet defects, including chipping, picking, sticking, cracking, lamination and capping.
Lamination and capping often occur during scale-up and are the main issues in the industry. Capping is the partial or complete removal of the crown of a tablet from the main body, while lamination is the separation of a tablet into two or more distinct layers. However, those two phenomena share similar causes.
It is a common hurdle in tabletting that is not generally observed during the research and development (R&D) phase. One of the reasons lie in the high production speeds on industrial rotary presses - speeds that are not generally seen on conventional R&D tablet presses. This explains why capping or lamination is sometimes only discovered during scale-up. It is therefore essential to try to identify those issues at the very early stage of development to avoid any extra costs in the development process.
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