There are numerous tablet defects, including chipping, picking, sticking, cracking, lamination and capping. Lamination and capping often occur during scale-up and are the main issues in the tabletting industry.
Capping is the partial or complete removal of the crown of a tablet from the main body, while lamination is the separation of a tablet into two or more distinct layers. However, these two phenomena share similar causes.
It is a common hurdle in tabletting that is not generally observed during the research and development (R&D) phase. One of the reasons lies in the high production speeds on industrial rotary presses, speeds that are not generally seen on conventional R&D tablet presses.
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