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Using Multi-Layer Tab-in-Tab or Tablets for Extended Release Formulations

Many options exist depending on the nature of the active pharmaceutical ingredient (API) and the required release profile properties, including hydrophilic or lipophilic matrices, osmotic pumps, coated tablets or pellets with pH-sensitive polymers.

However, even with only one API, it is still possible to make two different formulations and locate them in two different layers of a tablet. One layer can be immediate release, whereby the second one being an extended release formulation.

Delivery systems like Geomatrix™ from Skyepharma (Vectura Group) are based on a three-layer tablet. Here, the API is located in the centre layer with a swellable formulation whereby the two outer layers are only excipients controlling the surface area and therefore the release rate of the drug.



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