Bridge Biotherapeutics and Boehringer Ingelheim have mutually agreed to terminate their previously signed collaboration and licence agreement to develop BBT-877.

In July 2019, Boehringer entered a deal with Bridge Biotherapeutics to develop the drug candidate, BBT-877, for the treatment of fibrosing interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF).

According to the deal, Boehringer agreed to make upfront and near-term payments of €45m to Bridge Biotherapeutics. This deal included milestone payments of up to €1.1bn.

BBT-877 is an autotaxin inhibitor being trialled for the treatment of idiopathic pulmonary fibrosis and various fibrotic diseases.

Under the latest deal, Bridge Biotherapeutics will regain all rights to the drug candidate.

In the pre-clinical models for fibrosing interstitial lung diseases, the novel therapy yielded positive safety and efficacy data.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

The compound also demonstrated potential for use in combination with the current standard of care.

Bridge Biotherapeutics CEO James Lee said: “Bridge Biotherapeutics is committed to further develop BBT-877 to benefit patients with IPF, whom we want to serve.

“After receiving and reviewing data and dossiers, we will closely work with regulatory authorities to clarify future development plan and necessary studies to initiate human trials in the future.”

If implemented, the deal is believed to have expanded Boehringer’s IPF portfolio, which includes antifibrotic drug Ofev (nintedanib).

Bridge Biotherapeutics develops novel therapeutics in areas with high unmet needs such as ulcerative colitis, fibrotic diseases and cancers.

Apart from BBT-877, the company is developing a Pellino-1 inhibitor BBT-401 for the treatment of ulcerative colitis as well as BBT-176, a potent targeted cancer therapy for non-small cell lung cancer (NSCLC) with C797S EGFR mutations.