The VRBPAC recommendation is based on the totality of scientific data shared by Moderna. Credit: pearson0612 / Pixabay.

American pharmaceutical and biotechnology company Moderna has started an early-stage study of a new Covid-19 vaccine candidate.

The company has dosed the first patients in the Phase I study of mRNA-1283, which is being developed as a potential refrigerator stable mRNA vaccine to enable easier distribution.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

The study will evaluate the safety and immunogenicity of mRNA-1283 at three dose levels.

The vaccine candidate will be administered at 10µg, 30µg, and 100µg doses on healthy adults as a two-dose series with a gap of 28 days, as well as one dose at 100µg.

The results will be compared with the currently authorised two-dose series of 100µg of mRNA-1273.

Moderna CEO Stéphane Bancel said: “We are pleased to begin this Phase I study of our next generation Covid-19 vaccine candidate, mRNA-1283.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

“Our investments in our mRNA platform have enabled us to develop this next generation vaccine candidate, which is a potential refrigerator-stable vaccine that could facilitate easier distribution and administration in a wider range of settings, including potentially for developing countries.”

mRNA-1283 encodes for the portions of the SARS-CoV-2 spike protein critical for neutralisation, specifically the Receptor Binding Domain (RBD) and N-terminal Domain (NTD).

In future, the company plans to test the efficacy of mRNA-1283 for use as a booster dose for previously vaccinated as well as seropositive individuals.

Last week, Moderna began dosing the first subjects in a study assessing its Covid-19 booster vaccine candidates. Subjects are being enrolled by amending the ongoing Phase II clinical study.