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  1. FDA greenlight for esketamine sheds light on ketamine’s potential

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Janssen’s esketamine nasal spray not recommended by NICE for NHS use

The UK’s pricing regulator the National Institute for Health and Clinical Excellence (NICE) has decided to not recommend Janssen’s Spravato (esketamine) nasal spray in combination with an oral antidepressant for adults with treatment-resistant major depressive disorder for routine National Health Service (NHS) use.

FDA greenlight for esketamine sheds light on ketamine’s potential

In March, the FDA approved Janssen Pharmaceuticals’ depression drug esketamine, a form of ketamine for use as a treatment for depression. Billed as the most exciting antidepressant in decades, the drug has an entirely new mechanism of action. So what does esketamine offer, and why is the FDA so sure the benefits outweigh the risks?

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