Kiniksa Pharmaceuticals has reported that the Phase III segment of Phase II/III trial analysing mavrilimumab in Covid-19-linked acute respiratory syndrome (ARDS) failed to meet the primary efficacy goal. An experimental fully human monoclonal antibody, mavrilimumab acts on the granulocyte macrophage-colony stimulating factor receptor alpha (GM-CSFRα). The proportion of subjects alive and mechanical ventilation free at day 29 was the primary efficacy goal. The trial analysed the safety and efficacy of the therapy to treat adult Covid-19 patients with hypoxia and severe pneumonia/hyper inflammation in the hospital setting.
The United Arab Emirates (UAE) has granted emergency use authorization to Sinopharm’s protein-based Covid-19 vaccine as a booster dose. The shot will be made available in the region from January next year, Reuters quoted the UAE health ministry as saying. The approval is based on a trial in the UAE that enrolled people who received two doses of the vaccine. In the UAE, the vaccine will be manufactured and supplied by a joint venture between Group 42 and Sinopharm unit China National Biotec Group.