Study Demonstrates Velcade’s Effectiveness Against Multiple Myeloma

9 May 2011 (Last Updated May 9th, 2011 18:30)

US-based Takeda Oncology Company has announced positive results from a randomised Phase III trial of Velcade (bortezomib) as a treatment of multiple myeloma in patients who have had an autologous stem cell transplant. The study involved 370 patients who were randomised to receive Velca

US-based Takeda Oncology Company has announced positive results from a randomised Phase III trial of Velcade (bortezomib) as a treatment of multiple myeloma in patients who have had an autologous stem cell transplant.

The study involved 370 patients who were randomised to receive Velcade or a placebo.

The results showed that 45% of patients in the Velcade arm achieved a complete response or near complete response, compared to 35% of patients in the control group.

The drug, a proteasome inhibitor, led to significant improvements in response rates and progression-free survival.

The adverse effects seen in patients receiving Velcade include thrombocytopenia, neutropenia, peripheral neuropathy, neuralgia, pyrexia, leukopenia, dyspnea, insomnia and peripheral oedema.