Takeda Pharmaceutical Company Limited has launched two new drugs in Japan – Rozerem, to treat insomnia, and Metact, for the treatment of type 2 diabetes.
Rozerem works by selectively targeting two melatonin receptors in the brain, MT1 and MT2, which regulate circadian (24-hour) rhythms, including the sleep-wake cycle.
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The drug was first approved by the US Food and Drug Administration in July 2005, and is the first and only prescription sleep the medication that is classified as a non-controlled substance, showing no evidence of abuse or dependence.
Metact is a fixed-dose combination tablet of Actos with Metformin, and is the first treatment of this type that has been approved in Japan for type 2 diabetes.
The combined sales of these products are to be estimated several billion yen.
Takeda Pharmaceutical Marketing Division senior vice-president Yasuhiko Yamanaka said that the launch of Rozerem will mark the company’s full-scale entry into the Japanese central nervous system market, one of its core therapeutic areas.
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