Geron Corporation has enrolled the first patient in its Phase II clinical trial of imetelstat as maintenance therapy following platinum-based induction therapy for patients with non-small cell lung cancer.
The randomised, open label and multi-centric trial will test the effect of imetelstat on preventing or delaying tumour regrowth following debulking chemotherapy by targeting cancer stem cells.
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The trial is designed to compare the efficacy maintenance treatment with imetelstat including standard of care against against standard of care alone in patients
with advanced non-small cell lung cancer who have not progressed after completing first-line induction chemotherapy.
Patients will be administered imetelstat at 9.4 mg/kg on days one and eight of a 21-day treatment cycle.
The primary efficacy endpoint for the trial will be the estimate of median progression-free survival for patients receiving imetelstat as maintenance therapy.
Secondary endpoints will be the objective response and time to all-cause mortality.
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By GlobalDataAn estimated 96 patients are to be enrolled from 20 clinical sites across the US for this clinical trial.
