Seattle Genetics has halted the development of Lintuzumab for treatment of acute myeloid leukaemia in older patients following poor results in a Phase IIb trial.
The monoclonal antibody, given in combination low-dose cytarabine chemotherapy, did not meet the primary endpoint of extending overall survival when compared with low-dose cytarabine chemotherapy plus a placebo.
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The double-blind, multi-centre, randomised and placebo-controlled trial involved 211 patients with acute myeloid leukaemia aged 60 years and older, who were ineligible for intensive chemotherapy.
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