Adaptimmune has patented a method to predict potential cross-reactivity of binding peptides in vivo. The method involves identifying binding motifs in target peptides and testing for off-target peptides to prevent unwanted side effects. This innovation aims to improve treatment efficacy and safety in human subjects. GlobalData’s report on Adaptimmune gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Adaptimmune, was a key innovation area identified from patents.
Method for predicting and preventing cross reactivity in peptide administration
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A recently granted patent (Publication Number: US11929151B2) outlines a method for treating diseases in human subjects by administering a binding peptide selected to bind to a target peptide presented by a human leukocyte antigen (HLA) while preventing unwanted side effects. The method involves identifying binding motifs in the target peptide, searching for off-target peptides with similar motifs, testing for potential cross-reactivity, and selecting a binding peptide predicted to not cause unwanted side effects in vivo. This selection process includes creating mutant peptides to determine tolerated and non-tolerated amino acids within the binding motif.
The patent further specifies that the HLA can be of class I or class II, and the binding peptide can be a T cell receptor (TCR), chimeric antibody receptor (CAR), monoclonal antibody, or bispecific immunotherapeutic agent. In particular, the method highlights the use of a soluble TCR, potentially fused with an immune effector domain such as anti-CD3 antibody fragment, for treating diseases like cancer. The alternative amino acids considered in the process are alanine or glycine, and the search for off-target peptides includes those of human origin or commonly present in humans, ensuring specificity and safety in the treatment process.
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