AIMab-7195 is a Monoclonal Antibody owned by Aimmune Therapeutics, and is involved in 4 clinical trials, of which 3 were completed, and 1 is ongoing.

AIMab-71955 is an anti-IgE/CD32b antibody that reduces both free and total IgE levels via suppression of IgE production via selective inhibition of IgE+B cell differentiation to IgE-secreting plasma cells and by improved sequestration of remaining free IgE via enhanced affinity and targeting of IgE for destruction by Fc gamma RIIb+liver sinusoidal endothelial cells (LSEC).

The revenue for AIMab-7195 is expected to reach a total of $412m through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the AIMab-7195 NPV Report.

AIMab-7195 was originated by Xencor and is currently owned by Aimmune Therapeutics. Xencor is the other company associated in development or marketing of AIMab-7195.

AIMab-7195 Overview

AIMab-7195 is under development for the treatment of food allergy. The drug candidate is administered through intravenous and subcutaneous routes. It is a humanized monoclonal antibody that targets IgE and co-engages CD32b. The drug candidate utilizes XmAb technology to improve the activity of XmAb7195 by engineering its Fc region to improve binding affinity to Fc (gamma) receptors.

It was also under development for the treatment of allergic rhinitis, allergic conjunctivitis, atopic dermatitis and allergic asthma.

Xencor Overview

Xencor is a clinical stage biopharmaceutical company that focused on discovering and developing engineered monoclonal antibody and cytokine therapeutics to treat patients with cancer and autoimmune diseases. The company product pipeline includes Vudalimab (PD1 x CTLA4), Plamotamab (CD20 x CD3), XmAb819 (ENPP3 x CD3), XmAb564 (IL-2-Fc) and XmAb104 (PD1 x ICOS). Xencor‘s Vudalimab is a bispecific antibody that simultaneously targets immune checkpoint receptors PD-1 and CTLA-4 and is designed to promote tumor-selective T-cell activation. Its Plamotamab is a tumor-targeted antibody that contains both a CD20 binding domain and a cytotoxic T-cell binding domain (CD3). The company utilizes its proprietary XmAb technology platform to develop next generation antibody product candidates. . Xencor is headquartered in Monrovia, California, the US.

The company reported revenues of (US Dollars) US$275.1 million for the fiscal year ended December 2021 (FY2021), compared to a revenue of US$122.7 million in FY2020. The operating profit of the company was US$43 million in FY2021, compared to an operating loss of US$76.8 million in FY2020. The net profit of the company was US$82.6 million in FY2021, compared to a net loss of US$69.3 million in FY2020. The company reported revenues of US$27.3 million for the third quarter ended September 2022, a decrease of 9.5% over the previous quarter.

Quick View – AIMab-7195

Report Segments
  • Innovator
Drug Name
  • AIMab-7195
Administration Pathway
  • Intravenous
  • Subcutaneous
Therapeutic Areas
  • Dermatology
  • Immunology
  • Ophthalmology
  • Respiratory
Key Companies
Highest Development Stage
  • Phase I

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.