Anbenitamab is under clinical development by Alphamab Oncology and currently in Phase I for Gastroesophageal (GE) Junction Carcinomas. According to GlobalData, Phase I drugs for Gastroesophageal (GE) Junction Carcinomas have an 85% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Anbenitamab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Anbenitamab overview

KN-026 is under development for the treatment of gastric and gastroesophageal junction cancer, lung cancer, adenocarcinoma of the gastroesophageal junction, HER2 positive and HER2 low expressing metastatic breast cancer and gastroesophageal junction cancer, esophageal cancer, Metastatic colorectal cancer, esophageal squamous cell carcinoma , cervical cancer, pancreatic cancer, biliary tract cancer, ovarian cancer, endometrial cancer, urothelial cancer, liver cancer, extensive-stage small cell lung cancer, nasal pharyngeal cancer and lymphoma. The drug candidate is an anti-HER2 bi-specific monoclonal antibody. It is administered through intravenous route. It is developed based on CRIB (Charge repulsion induced bi-specificity) technology that is used to generate multi-fuctional antibodies or fusion proteins.

Alphamab Oncology overview

Alphamab Oncology (Alphamab) is a clinical-stage biopharmaceutical company that discovers, develops, manufactures and commercializes therapeutics for the treatment of cancer. The company’s pipeline products include KN035; an injectable PD-L1 inhibitor for the treatment of dMMR and MSI-H solid tumors, KN046; a BsAb immune checkpoint inhibitor, KN026; an anti-HER2 bispecific antibody. It also comprises KN019; a CTLA-4-based immunosuppressant fusion protein drug candidate used for treating indications such as autoimmune diseases and induced immune disorders. Alphamab offers JSKN-003, JSKN-001, JSKN-002, JSKN-004, JSKN-005, JSKN-006 and JSKN-008. The company appears its proprietary CRIB and CRAM platforms for bispecific and protein engineering and antibody screening to best-in-class medicines in oncology. Alphamab is headquartered in Suzhou, Jiangsu, China.

For a complete picture of Anbenitamab’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 7 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.