Belzutifan is under clinical development by Merck and currently in Phase II for Pancreatic Tumor. According to GlobalData, Phase II drugs for Pancreatic Tumor have a 25% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Belzutifan’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Belzutifan overview

Belzutifan (Welireg), is an inhibitor of hypoxia-inducible factor-2α (HIF-2α). It is formulated as film coated tablets for oral route of administration. Welireg is indicated for treatment of adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumors (pNET), not requiring immediate surgery.

MK-6482 (PT-2977) is under development for the treatment of clear cell renal cell carcinoma (ccRCC), von Hippel-Lindau disease-associated renal cell carcinoma, pancreatic ductal adenocarcinoma, hepatocellular carcinoma, endometrial cancer, esophageal squamous cell carcinoma, colorectal cancer, bile duct cancer (cholangiocarcinoma), gallbladder cancer, clear cell renal cell carcinoma, metastatic renal cell carcinoma, advanced pheochromocytoma/paraganglioma (PPGL), pancreatic neuroendocrine tumor (pNET), recurrent glioblastoma multiforme and rare cancers. It is a small molecule. It is administered through oral route. The drug candidate targets hypoxia-inducible factor-2 alpha (HIF-2alpha). It was also under development for the treatment of iron overload (hemosiderosis) and pulmonary arterial hypertension.

Merck overview

Merck is a biopharmaceutical company focused on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines and animal health products. It offers prescription products for therapy areas related to cardiovascular, cancer, immune disorders, infectious, respiratory and women’s diseases, and diabetes. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is known as MSD outside the US and Canada and is headquartered in Kenilworth, New Jersey, the US.

For a complete picture of Belzutifan’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.